41 - 45 Pharmacology SBAs for the Primary FRCA
Question 41
You are cautiously administering IV salbutamol to a patient with life-threatening asthma in the Emergency Department, when a curious bystander asks you about adenylate cyclase.
Which of the following is true?
- Adenylate cyclase is activated directly by catecholamines
- Adenylate cyclase is a membrane-bound protein
- Aminophylline stimulates phosphodiesterase to break cAMP down to 5'-AMP
- Adenylate cyclase catalyses production of ATP from cAMP
- Salbutamol stimulates beta-2 receptors, resulting in an indirect reduction in adenylate cyclase activity
Answer
- Adenylate cyclase is a membrane bound protein
There is also a cytosolic version, but that doesn't stop the above from being true I guess.
- Adenylate cyclase is indirectly activated by catecholamines
- Aminophylline inhibits phosphodiesterase
- Adenylate cyclase catalyses production of cAMP from ATP
- Salbutamol stimulates beta-2 receptors, resulting in an indirect increase in adenylate cyclase activity